Group Publications 2005-2010

1. D. Vourloumis, G.C. Winters, K.B. Simonsen, M. Takahashi, B. Ayida, S. Shandrick, Q. Zhao, Q. Han, T. Hermann, “Aminoglycoside-Hybrid Ligands Targeting the Ribosomal Decoding Site.” ChemBioChem 2005, 6, 58–65.
2. Q. Han, Q. Zhao, S. Shandrick, K.B. Simonsen, D. Vourloumis, J.M. Froelich, D. Wall, T. Hermann, “Molecular Recognition by Glycoside Pseudo Base Pairs and Triples in an Apramycin-RNA Complex.” Angew. Chem. Int. Ed. 2005, 44, 2694–2700.
3. B. Ayida, K.B. Simonsen, D. Vourloumis, T. Hermann, “Synthesis of dehydroalanine fragments as thiostrepton side chain mimetics.” Bioorg. Med. Chem. Lett. 2005, 15, 2457–2460.
4. Y. Zhou, V.E. Gregor, Z. Suyn, B.K. Ayida, G.C. Winters, D. Murphy, K.B. Simonsen, D. Vourloumis, S. Fish, J.M. Froelich, D. Wall, T. Hermann, “Structure-guided discovery of novel aminoglycoside mimetics as antibacterial translation inhibitors.” Antimicrob. Agents Chemother. 2005, 49, 4942–4949.
5. Katsarou M.E., Papakyriakou A., Katsaros N., and Scorilas., A “Expression of the C-terminal domain of novel human SR-A1 protein: Interaction with the CTD domain of RNA Polymerase II” Biochem Biophys Res Commun. 2005 Aug 19; 334 (1):61-8.
6. Bratsos I., Zangrando E., Serli B., Katsaros N and Alessio E., “The unprecedented bridging coordination mode of 1,1-cyclobutane dicarboxylate .(μ-cbdc-o,o’) stabilized by intramolecular hydrogen bonds in ruthenium (II) complexes”, Dalton Transactions 2005 (24), 3881-3885.
7. P. Christofis, M. Katsarou, A. Papakyriakou, Y. Sanakis, N. Katsaros, G. Psomas, “Mononuclear Metal Complexes with the Non-Steroidal Anti-Inflammatory Drug Piroxicam: Synthesis, Structure and Biological activity”, J. Inorg. Biochem., 2005, 99, 2197-2210.
8. Efthimiadou E. K., Sanakis Y., Katsarou Μ., Raptopoulou C. P., Karaliota Α., Katsaros N. and Psomas G., “Neutral and Cationic Mononuclear Copper(II) Complexes with Enrofloxacin: Structure and Biological Activity.” J. Inorg. Biochem. 2006, 100, 1378-88.
9. Efthimiadou Ε. Κ, Sanakis Υ., Raptopoulou Κ., Karaliota Α., Katsaros N. and Psomas G., “Crystal Structure, Spectroscopic and Biological Study of theCopper(II) Complex with Third-Generation Quinolone Antibiotic Sparfloxacin.” Bioorg. Med. Chem. Lett. 2006, 14, 3864-3867.
10. Psomas G., Tarushi A., Efthimiadou E.K., Sanakis Y., Raptopoulou C.P., Katsaros N., “Synthesis, Structure and Biological Activity of Copper(II) Complexes with Oxolinic Acid.”, J. Inorg. Biochem. 2006, 100, 1764-1773.
11. Efthimiadou Ε.Κ, Thomadaki H., Sanakis Y., Raptopoulou C.P., Katsaros N., Scorilas A., Karaliota A., Psomas G., “Structure and biological properties of the copper(II) complex with the quinolone antibacterial drug N-propyl-norfloxacin and 2,2’-bipyridine.” J. Inorg. Biochem. 2007, 101, 64-73.
12. Efthimiadou Ε.Κ, Sanakis Y., Katsaros N., Karaliota A., Psomas G., “Transition metal complexes with the quinolone antibacterial agent pipemidic acid: Synthesis, characterization and biological activity”, Polyhedron 2007, 26, 1148-1158.
13. Efthimiadou Ε.Κ, Psomas G., Sanakis Y., Katsaros N., Karaliota A., “Metal complexes with the quinolone antibacterial agent N-propylnorfloxacin: Synthesis, structure and bioactivity”, J. Inorg. Biochem. 2007, 101, 525-535.
14. Katsarou M.E., Efthimiadou Ε.Κ., Psomas G., Karaliota A., Vourloumis D., “Novel Copper(II) Complex of N-Propyl-norfloxacin and 1,10-Phenanthroline with Enhanced Antileukemic and DNA Nuclease Activities”, J. Med. Chem. 2008, 51, 470-478.
15. E.K. Efthimiadou, M.E. Katsarou, M. Fardis, C. Zikos, E.N. Pitsinos, A. Kazantzis, L. Leondiadis, M. Sagnou, D. Vourloumis, “Synthesis and characterization of novel natural product-Gd(III) MRI contrast agent conjugates.” Bioorg. Med. Chem. Lett. 2008, 18, 6058-6061.
16. Psomas G, Alketa Tarushi, Efthimiadou E. K., “Synthesis, characterization and DNA-binding of the mononuclear dioxouranium(VI) complex with ciprofloxacin”, Polyhedron 2008, 27, 133-138.
17. Efthimiadou E.K., Karaliota A., Psomas G., “Mononuclear dioxomolybdenium(VI) complexes with the quinolones enrofloxacin and sparfloxacin: Synthesis, structure, antibacterial activity and interaction with DNA”, Polyhedron 2008, 27, 349-356.
18. Evnouchidou I., Momburg F., Papakyriakou A., Chroni A., Leondiadis L., Chang S-C., Goldberg A. L., Stratikos E., “The Internal Sequence of the Peptide Determines N-Terminus Cleavage by ERAP1” PLoS ONE, 2008, 3, e3658.
19. Efthimiadou E. K., Katarou M. E., Karaliota A., Psomas G., “Copper(II) complexes with sparfloxacin and nitrogen-donor heterocyclic ligands: Structure-activity relationships”, J. Inorg. Biochem. 2008, 102, 910-920.
20. Theodossiou T. A., Papakyriakou A., Hothersall J. S., “Molecular modeling and experimental evidence for hypericin as a substrate for mitochondrial complex III; mitochondrial photodamage as demonstrated using specific inhibitors”, Free Radic. Biol. Med. 2008, 45, 1581-1590.
21. Efthimiadou E. K., Karaliota A., Psomas G., “Mononuclear metal complexes of the second-generation quinolone antibacterial agent enrofloxacin: Synthesis, structure, antibacterial activity and interaction with DNA”, Polyhedron 2008, 27, 1729-1738.
22. Efthimiadou E. K., Karaliota A., Psomas G., “Structure, antimicrobial activity and DNA-binding properties of the cobalt(II)–sparfloxacin complex”, Bioorg. Med. Chem. Lett. 2008, 18, 4033-4037.
23. Papakyriakou, D. Vourloumis, F. Tzortzatou-Stathopoulou, M. Karpusas, “Conformational dynamics of the EGFR kinase domain reveals structural features involved in activation.” Proteins: Structure and Bioinformatics 2009, 76, 375-386.
24. Evnouchidou I., Papakyriakou A., Stratikos E., “A new role for Zn(II) aminopeptidases: Antigenic peptide generation and destruction” Curr. Pharm. Design 2009, 15 (31), 3656-3670.
25. Dalkas, G.A., Papakyriakou, A., Vlamis-Gardikas, A., Spyroulias, G.A. “Insights into the anthrax lethal factor-substrate interaction and selectivity using docking and molecular dynamics simulations”, Protein Science 2009, 18 (8), 1774-1785.
26. Katsoulis, I.A.; Pyrkotis, C.; Papakyriakou, A.; Kythreoti, G.; Zografos, A.L.; Mavridis, I.; Nahmias, V.R.; Anastasopoulou, P.; Vourloumis, D., “Unnatural rigid scaffolds targeting the bacterial ribosome”, ChemBioChem 2009, 10, 1969-1972.
27. Papakyriakou, M.E. Katsarou, M. Belimezi, M. Karpusas, D. Vourloumis, “Discovery of Potent Vascular Endothelial Growth Factor Receptor-2 Inhibitors Assisted by Computational Methods”, ChemMedChem 2010, 5, 118-129.
28. V. P. Androutsopoulos, A. Papakyriakou, D. Vourloumis, A. M. Tsatsakis, D. A. Spandidos, “Dietary flavonoids in cancer therapy and prevention: Substrates and inhibitors of cytochrome P450 CYP1 enzymes”, Pharmacology & Therapeutics 2010, 126, 9-20.
29. Stathakis, C.I; Mavridis, I.; Kythreoti, G.; Papakyriakou, A.; Katsoulis, I.A.; Cottin, T.; Anastasopoulou, P.; Vourloumis, D., “Second generation analogues of rigid 6,7-spiro scaffolds targeting the bacterial ribosome”, Bioorg. Med. Chem. Lett. 2010, 20, 7488-7492.
30. A. Kokkinou, F. Tsorteki, M. Karpusas, A. Papakyriakou, K. Bethanis, D. Mentzafos, “Study of the inclusion of the (R)- and (S)-camphor enantiomers in alpha-cyclodextrin by X-ray crystallography and molecular dynamics”, Carbohydr Res. 2010, 345(8), 1034-1040.